Selective-recruitment designs

Selective recruitment designs try to estimate how much statistical information a person is likely to provide on a clinical study. Individuals that are considered to be sufficiently informative are recruited, otherwise they are rejected. A selective recruitment design results in a cohort that is enriched for statistically informative individuals.

The advantage of such an approach is that fewer recruits are required to achieve a successful clinical study. This can have potential economic savings and ethical advantages. Selective recruitment designs provide a flexible adaptive framework for efficiently establishing statistical associations between treatments and clinical outcomes.

For further details please see this publication (link). For applications to trials with binary outcomes see here (link).