Epigenetic heterogeneity and phylogenetics
Quantification of tumour heterogeneity and phylogenetic inference in terms of DNA methylation in lung cancer as part of the TRACERx project. These approach uses Bayesian detection of epialleles. See the manuscript here for further details. Code is available here.
Analysis of FRET/FLIM, PET/CT imaging datasets. Integration with mathematical models of biological signalling pathways. Mostly applied to the EGFR network. Work with Tony Ng at the CCIC.