Publications

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction

Sanjay Tewari, George Renney, John Brewin, Kate Gardner, Fenella Kirkham, Baba Inusa, James E Barrett, Stephan Menzel, Swee Lay Thein, Malcolm Ward, David C Rees, Haematologica 2018 103:xxx, doi 10.3324/haematol.2018.187815. Link to website.


Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection

James E. Barrett, Andrew Feber, Javier Herrero, Miljana Tanic, Gareth Wilson, Charles Swanton, TRACERx Consortium, Stephan Beck, BMC Bioinformatics 2017 18:354, doi 10.1186/s12859-017-1753-2. Link to website.


Information-adaptive clinical trials with selective recruitment and binary outcomes.

J Barrett, Statistics in Medicine 2017 36: 2803–2813. doi: 10.1002/sim.7353. Link to website or arXiv pdf.


Replica analysis of overfitting in regression models for time-to-event data

ACC Coolen, JE Barrett, P Paga, CJ Perez-Vicente, Journal of Physics A: Mathematical and Theoretical 2017 50 375001 (38pp). Link to website or  arXiv pdf.


Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L. Worth, Caroline Schweiger, Sandra Liebs, Martin Lange, Hans- Jörg Warnatz, Lee M. Butcher, James E. Barrett, Marc Sultan, Christoph Wierling, Nicole Golob-Schwarzl, Sigurd Lax, Stefan Uranitsch, Michael Becker, Yvonne Welte, Joseph Lewis Regan, Maxine Silvestrov, Inge Kehler, Alberto Fusi, Thomas Kessler, Ralf Herwig, Ulf Landegren, Dirk Wienke, Mats Nilsson, Juan A. Velasco, Pilar Garin-Chesa, Christoph Reinhard, Stephan Beck, Reinhold Schäfer, Christian R. A. Regenbrecht, David Henderson, Bodo Lange, Johannes Haybaeck, Ulrich Keilholz, Jens Hoffmann, Hans Lehrach, Marie-Laure Yaspo, Nature Communications 2017, doi:10.1038/ncomms14262. Link to website.


eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

Charles E. Breeze, Dirk S. Paul, Jenny van Dongen, Lee M. Butcher, John C. Ambrose, James E. Barrett, Robert Lowe, Vardhman K. Rakyan, Valentina Iotchkova, Mattia Frontini, Kate Downes, Willem H. Ouwehand, Jonathan Laperle, Pierre-Étienne Jacques, Guillaume Bourque, Anke K. Bergmann, Reiner Siebert, Edo Vellenga, Sadia Saeed, Filomena Matarese, Joost H.A. Martens, Hendrik G. Stunnenberg, Andrew E. Teschendorff, Javier Herrero, Ewan Birney, Ian Dunham, Stephan Beck, Cell Reports 2016, DOI: 10.1016/j.celrep.2016.10.059. Link to website.


Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy

Ruobing Zhang, Gilbert O. Fruhwirth, Oana Coban, James E. Barrett, Thomas Burgoyne, Sang Hak Lee, Paul Dennis Simonson, Murat Baday, Boris N. Kholodenko, Clare E. Futter, Tony Ng, and Paul R. Selvin, ACS Nano 2016, DOI: 10.1021/acsnano.6b05356. Link to website.


Information-adaptive clinical trials: a selective recruitment design.

J Barrett, Royal Statistical Society Series C 2016, DOI: 10.1111/rssc.12146. Link to website or arXiv pdf.


Covariate dimension reduction for survival data via the Gaussian process latent variable model.

J Barrett and ACC Coolen, Statistics in Medicine 2015, DOI: 10.1002/sim.6784. Link to website or arXiv pdf.


Multiple output Gaussian process regression for survival data with competing risks.

J Barrett and ACC Coolen, manuscript in preparation. Link to arXiv pdf.


Imaging tumour heterogeneity of the consequence of a PKCα-substrate interaction in breast cancer patients.

G Weitsman, K Lawler, E Shamil, M Kelleher, P Barber, J Barrett, F Festy, G Patel, G Fruhwirth, L Huang, I Tullis, N Woodman, E Ofo, S Ameer-Beg, S Irshad, C Gillett, P Ellis, B Vojnovic, ACC Coolen, T Ng, Biochemical Society Transactions (2014) 42, 1498–1505. Link to website.


Time dependent breast cancer metastasis prediction using novel biological imaging, clinico-pathological and genomic data combined with Bayesian modeling to reduce over-fitting and improve on inter-cohort reproducibility.

I Sheeba, M Kelleher, K Lawler, F Festy, P Barber, E Shamill, P Gargi, G Weitsman, J Barrett, G Fruhwirth, L Huang, I Tullis, N Woodman, S Pinder, E Ofo, L Fernandes, M Beutler, S Ameer-Beg, L Holmberg, A Purushotham, F Fraternali, J Condeelis, A Hanby, C Gillett, P Ellis, B Vojnovic, A Coolen, and T Ng, Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-29. Link to website.

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